The United States Geological Survey reported a magnitude 3.2 earthquake about 7 miles west of Edgefield around 3:23 p.m. Sunday.
This after a magnitude 4.1 earthquake shook much of the state Friday night.
Sunday's earthquake was only felt about 35 miles from its center, while Friday's quake was reported more than 150 miles away.
Inspectors checked bridges, nuclear plants and dams in the area, but no major damage was reported after Friday's quake.
The most powerful quake in recorded history to hit South Carolina occurred on August 31, 1886, according to the South Carolina Department of Natural Resources. A quake with an estimated magnitude of 7.6 was centered near Summerville, SC.
Approximately 60 people died as a result of the quake. It was reported that ground shaking damaged structures as far away as 200 miles from Charleston. It was the strongest earthquake known to hit the east coast.
Earthquakes in the central and eastern U.S., although less frequent than in the western U.S., are typically felt over a much broader region.
Earthquakes everywhere occur on faults within bedrock, usually miles deep. Most bedrock beneath the inland Carolinas was assembled as continents collided to form a supercontinent about 500-300 million years ago, raising the Appalachian Mountains.